Swine are considered to be one of the major animal species used in translational research surgical models and procedural training and are increasingly being used as an alternative to the dog or monkey as the choice of nonrodent species in preclinical toxicologic testing of pharmaceuticals. Swine in biomedical research management and models introduction for the last 2 decades swine have been used with increasing frequency in biomedical research as biomedical models swine are commonly used in cardiovascular research because swine and humans share important anatomic husbandry . Swine as models in biomedical research and toxicology testing vet pathol 2012 49344 356 doi 101177 0300985811402846 in the above article figure 1 was missing the citation of its source . Over the last 20 years swine have also replaced dogs as the general surgical model in the international arena for both train ing and research textbooks article and proceedings detailing a large number of models and technical procedures for using swine in the laboratory are available2147505253 there is a. Abstract this chapter provides an overview of the use of domestic and miniature breeds of swine in biomedical research differences between breeds of pigs and the most significant anatomic and physiological characteristics of the species related to their selection as biomedical research models are discussed