Portal hypertension once it develops is the source of potentially devastating complications that include life threatening hemorrhage infection renal failure and coma parenchymal disease can result in coagulopathy as well as altered handling of both endogenous hormones metabolites and exogenous drugs substances cirrhosis also can be complicated by the development of hcc which may worsen portal hypertension deplete parenchymal reserves and result in catastrophic complications . Can lead to other complications of chronic liver dis ease including the development of varices and variceal bleeding ascites and spontaneous bacterial peritonitis. Complications of chronic liver disease include portal hypertension variceal bleeding ascites spontaneous bacterial peritonitis hepatorenal syndrome hepatic encephalopathy hepatopulmonary syndrome portopulmonary hypertension cirrhotic cardiomyopathy and malnutrition. The predominant complications of chronic liver disease and cirrhosis result primarily from two major processes 1 impaired hepatic parenchymal function including plasma protein synthetic function and biliary excretion and 2 development of portal hypertension